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Immunobiology of naïve and genetically modified HLA-class-I-knockdown human embryonic stem cells

30 Aug 2011

Abstract excerpt

Human embryonic stem cells (hESCs) can serve as a universal cell source for emerging cell or tissue replacement strategies, but immune rejection of hESC derivatives remains an unsolved problem. Here, we sought to describe the mechanisms of rejection for naïve hESCs and upon HLA class I (HLA I) knockdown (hESC(KD)). hESCs were HLA I-positive but negative for HLA II and co-stimulatory molecules. Transplantation of...

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PMID: 21878509
DOI: 10.1242/jcs.087718

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