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PD ‐ L1 Promotes Immunological Tolerance and Enhances Visual Protection of hESC ‐ RPE Grafts in Retinal Degeneration

14 Feb 2025

Abstract excerpt

Immune rejection is a major barrier to the successful human embryonic stem cell-derived retinal pigment epithelial (hESC-RPE) transplantation for age-related macular degeneration (AMD). Traditional strategies to mitigate immune rejection involve ablating major histocompatibility complex (MHC) molecules on hESC-RPE. An alternative approach is immune checkpoint overexpression, avoiding natural killer (NK)...

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PMID: 39953740
DOI: 10.1111/cpr.70007

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