Article

B2M or CIITA knockdown decreased the alloimmune response of dental pulp stem cells: an in vitro study

2024-07-29

Abstract excerpt

<title>Abstract</title> <p>Background Dental pulp stem cells (DPSCs) have acquired noteworthy attention for their application in treating ischemic diseases and facilitating tissue regeneration. However, the host’s immune response following allogenic DPSC transplantation often handicaps the long-term survival of transplanted cells, thereby limiting the application of DPSCs in cell therapy. This study aims to inve...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 60be644c-c487-52bb-a673-769ad67b652a
DOI: 10.21203/rs.3.rs-4598455/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

B2M or CIITA knockdown decreased the alloimmune response of dental pulp stem cells: an in vitro studyDOI 10.21203/rs.3.rs-4598455/v1Read

Derivation of induced pluripotent stem cells line (RCPCMi007-A-1) with inactivation of the beta-2-microglobulin gene by CRISPR/Cas9 genome editingSemantic proximity Read

CRISPR-Cas9-mediated disruption of B2M and CIITA genes eliminates HLA class I and II expression in human induced pluripotent stem cells (MUSIi001-A-2)Semantic proximity Read

Hypoimmunogenic human iPSCs expressing HLA-G, PD-L1, and PD-L2 evade innate and adaptive immunitySemantic proximity Read

iPSC modification strategies to induce immune toleranceSemantic proximity Read

B2M gene knockout in HEK293T cells by non-viral delivery of CRISPR-Cas9 for the induction of universal cellSemantic proximity Read

Generation of universal and hypoimmunogenic human pluripotent stem cellsSemantic proximity Read

Diminished expression of major histocompatibility complex facilitates the use of human induced pluripotent stem cells in monkeySemantic proximity Read

iPS Cells—The Triumphs and TribulationsSemantic proximity Read

Hypoimmunogenic Human Pluripotent Stem Cells as a Powerful Tool for Liver Regenerative MedicineSemantic proximity Read

Embryonic Stem Cells: Overcoming the Immunological Barriers to Cell Replacement TherapySemantic proximity Read

Generation of hypoimmunogenic induced pluripotent stem cells by CRISPR-Cas9 system and detailed evaluation for clinical applicationSemantic proximity Read

Generation of hypoimmunogenic universal iPSCs through HLA-type gene knockoutSemantic proximity Read