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Article

Trithorax maintains the functional heterogeneity of neural stem cells through the transcription factor buttonhead.

eLife - 6 Oct 2014

Komori Hideyuki, Xiao Qi, Janssens Derek H, Dou Yali, Lee Cheng-Yu

Abstract excerpt

The mechanisms that maintain the functional heterogeneity of stem cells, which generates diverse differentiated cell types required for organogenesis, are not understood. In this study, we report that Trithorax (Trx) actively maintains the heterogeneity of neural stem cells (neuroblasts) in the developing Drosophila larval brain. trx mutant type II neuroblasts gradually adopt a type I neuroblast functional...

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Identifiers

PMID: 25285447
DOI: 10.7554/eLife.03502
PMCID: PMC4221733

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