Article
Immune-checkpoint HLA-G gene polymorphisms, 3'-UTR types and their association with hepatocellular carcinoma and treatment response in Indian population.
Frontiers in immunology - 1 Jan 2024
Nadda Neeti, Yadav Renu, Roy Neelanjana, Singh Nita, Kumar Sonu, Paul Shashi Bala, Gamanagatti Shivanand, Saraya Anoop, Shalimar, Nayak Baibaswata
Abstract excerpt
Background: Human leukocyte antigen-G (HLA-G) is a cancer-associated immune checkpoint protein implicated in tumor-driven immune escape mechanisms. This study was undertaken to determine genetic variations at the 3'-UTR of the HLA-G gene that may alter its expression, identify risk alleles and genotypes for their association with hepatocellular carcinoma (HCC), and treatment responses in the Indian population....
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