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Article

HLA-G 3'UTR Polymorphisms Impact the Prognosis of Stage II-III CRC Patients in Fluoropyrimidine-Based Treatment.

PloS one - 1 Jan 2015

Garziera Marica, Bidoli Ettore, Cecchin Erika, Mini Enrico, Nobili Stefania, Lonardi Sara, Buonadonna Angela, Errante Domenico, Pella Nicoletta, D'Andrea Mario, De Marchi Francesco, De Paoli Antonino, Zanusso Chiara, De Mattia Elena, Tassi Renato, Toffoli Giuseppe

Abstract excerpt

An important hallmark of CRC is the evasion of immune surveillance. HLA-G is a negative regulator of host's immune response. Overexpression of HLA-G protein in primary tumour CRC tissues has already been associated to worse prognosis; however a definition of the role of immunogenetic host background is still lacking. Germline polymorphisms in the 3'UTR region of HLA-G influence the magnitude of the protein by...

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Identifiers

PMID: 26633805
DOI: 10.1371/journal.pone.0144000
PMCID: PMC4669157

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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