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Article

Structural basis of mRNA recognition and cleavage by toxin MazF and its regulation by antitoxin MazE in Bacillus subtilis.

Molecular cell - 7 Nov 2013

Simanshu Dhirendra K, Yamaguchi Yoshihiro, Park Jung-Ho, Inouye Masayori, Patel Dinshaw J

Abstract excerpt

MazF is an mRNA interferase, which, upon activation during stress conditions, cleaves mRNAs in a sequence-specific manner, resulting in cellular growth arrest. During normal growth conditions, the MazF toxin is inactivated through binding to its cognate antitoxin, MazE. How MazF specifically recognizes its mRNA target and carries out cleavage and how the formation of the MazE-MazF complex inactivates MazF remain...

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Identifiers

PMID: 24120662
DOI: 10.1016/j.molcel.2013.09.006
PMCID: PMC4691852

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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