Article
RNA thermoswitches modulate Staphylococcus aureus adaptation to ambient temperatures.
Nucleic acids research - 6 Apr 2021
Catalan-Moreno Arancha, Cela Marta, Menendez-Gil Pilar, Irurzun Naiara, Caballero Carlos J, Caldelari Isabelle, Toledo-Arana Alejandro
Abstract excerpt
Thermoregulation of virulence genes in bacterial pathogens is essential for environment-to-host transition. However, the mechanisms governing cold adaptation when outside the host remain poorly understood. Here, we found that the production of cold shock proteins CspB and CspC from Staphylococcus aureus is controlled by two paralogous RNA thermoswitches. Through in silico prediction, enzymatic probing and...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.