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Female ageing affects the DNA repair capacity of oocytes in IVF using a controlled model of sperm DNA damage in mice

30 Dec 2019

Abstract excerpt

STUDY QUESTION: Does female ageing have a negative effect on the DNA repair capacity of oocytes fertilised by spermatozoa with controlled levels of DNA damage? SUMMARY ANSWER: Compared to oocytes from younger females, oocytes from older females have a reduced capacity to repair damaged DNA introduced by spermatozoa. WHAT IS KNOWN ALREADY: The reproductive lifespan in women declines with age predominantly due to...

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PMID: 32108237
DOI: 10.1093/humrep/dez308

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