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Article

The I148M PNPLA3 Variant Forces Progressive Portal MASLD by Spatially Perturbing Metabolic Pathways Across Liver Zones.

International journal of molecular sciences - 6 Feb 2026

Paolini Erika, Meroni Marica, Longo Miriam, Badiali Sara, Maggioni Marco, Fracanzani Anna Ludovica, Dongiovanni Paola

Abstract excerpt

Genetics strongly impacts the course of metabolic dysfunction-associated steatotic liver disease (MASLD), with the I148M Patatin like phospholipase domain containing 3 (PNPLA3) variant representing the main modifier. Fat accumulation in the hepatic lobule, strongly enhanced by this SNP, may be influenced by the liver's zonation. Therefore, we applied spatial transcriptomics to investigate the metabolic processes...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41684020
DOI: 10.3390/ijms27031601
PMCID: PMC12897613

Genes

PNPLA3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

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The I148M PNPLA3 Variant Forces Progressive Portal MASLD by Spatially Perturbing Metabolic Pathways Across Liver Zones.PMID 41684020Read ↗

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Global epidemiology and implications of PNPLA3 I148M variant in MASLD: a systematic review and meta-analysisSemantic proximity Read ↗

A spatial transcriptomics atlas of live donors reveals unique zonation patterns in the healthy human liverSemantic proximity Read ↗

Role of PNPLA3 in Hepatic Stellate Cells and Hepatic Cellular CrosstalkSemantic proximity Read ↗

Hepatic patatin-like phospholipase domain-containing 3 levels are increased in I148M risk allele carriers and correlate with NAFLD in humans.Semantic proximity Read ↗

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PNPLA3 I148M variant in nonalcoholic fatty liver disease: demographic and ethnic characteristics and the role of the variant in nonalcoholic fatty liver fibrosis.Semantic proximity Read ↗

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