Primary mismatch repair deficient IDH-mutant astrocytoma (PMMRDIA) is a distinct type with a poor prognosis.

doi:10.1007/s00401-020-02243-6

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Article

Primary mismatch repair deficient IDH-mutant astrocytoma (PMMRDIA) is a distinct type with a poor prognosis.

Acta neuropathologica - 1 Jan 2021

Suwala Abigail K, Stichel Damian, Schrimpf Daniel, Kloor Matthias, Wefers Annika K, Reinhardt Annekathrin, Maas Sybren L N, Kratz Christian P, Schweizer Leonille, Hasselblatt Martin, Snuderl Matija, Abedalthagafi Malak Sameer J, Abdullaev Zied, Monoranu Camelia M, Bergmann Markus, Pekrun Arnulf, Freyschlag Christian, Aronica Eleonora, Kramm Christof M, Hinz Felix, Sievers Philipp, Korshunov Andrey, Kool Marcel, Pfister Stefan M, Sturm Dominik, Jones David T W, Wick Wolfgang, Unterberg Andreas, Hartmann Christian, Dodgshun Andrew, Tabori Uri, Wesseling Pieter, Sahm Felix, von Deimling Andreas, Reuss David E

Abstract excerpt

Diffuse IDH-mutant astrocytoma mostly occurs in adults and carries a favorable prognosis compared to IDH-wildtype malignant gliomas. Acquired mismatch repair deficiency is known to occur in recurrent IDH-mutant gliomas as resistance mechanism towards alkylating chemotherapy. In this multi-institutional study, we report a novel epigenetic group of 32 IDH-mutant gliomas with proven or suspected hereditary mismatch...

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PMID: 33216206
DOI: 10.1007/s00401-020-02243-6
PMCID: PMC7785563

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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