Article
Molecular landscape of IDH-mutant primary astrocytoma Grade IV/glioblastomas.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Jul 2021
Wong Queenie Hoi-Wing, Li Kay Ka-Wai, Wang Wei-Wei, Malta Tathiane M, Noushmehr Houtan, Grabovska Yura, Jones Chris, Chan Aden Ka-Yin, Kwan Johnny Sheung-Him, Huang Queenie Jun-Qi, Wong Gabriel Chun-Hei, Li Wen-Cai, Liu Xian-Zhi, Chen Hong, Chan Danny Tat-Ming, Mao Ying, Zhang Zhen-Yu, Shi Zhi-Feng, Ng Ho-Keung
Abstract excerpt
WHO 2016 classified glioblastomas into IDH-mutant and IDH-wildtype with the former having a better prognosis but there was no study on IDH-mutant primary glioblastomas only, as previous series included secondary glioblastomas. We recruited a series of 67 IDH-mutant primary glioblastomas/astrocytoma IV without a prior low-grade astrocytoma and examined them using DNA-methylation profiling, targeted sequencing, RNA...
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