Article
Mediation by differential DNA methylation of known associations between single nucleotide polymorphisms and bladder cancer risk.
BMC medical genetics - 19 Nov 2020
Jordahl Kristina M, Phipps Amanda I, Randolph Timothy W, Tinker Lesley F, Nassir Rami, Hou Lifang, Anderson Garnet L, Kelsey Karl T, White Emily, Bhatti Parveen
Abstract excerpt
BACKGROUND: Though bladder cancer has been the subject of many well-powered genome-wide association studies, the mechanisms involving bladder-cancer-associated single nucleotide polymorphisms (SNPs) remain largely unknown. This study focuses on rs798766, rs401681, rs2294008, and rs8102137, which have been associated with bladder cancer and are also cis-acting methylation quantitative loci (mQTL). METHODS: Among...
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