Article
A genome-wide association study identifies a locus on chromosome 14q21 as a predictor of leukocyte telomere length and as a marker of susceptibility for bladder cancer.
Cancer prevention research (Philadelphia, Pa.) - 1 Apr 2011
Gu Jian, Chen Meng, Shete Sanjay, Amos Christopher I, Kamat Ashish, Ye Yuanqing, Lin Jie, Dinney Colin P, Wu Xifeng
Abstract excerpt
Telomeres play a critical role in maintaining genome integrity. Telomere shortening is associated with the risk of many aging-related diseases. Classic twin studies have shown that genetic components may contribute up to 80% of the heritability of telomere length. In the study we report here that we used a multistage genome-wide association study to identify genetic determinants of telomere length. The mean...
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