Article
Common genetic polymorphisms modify the effect of smoking on absolute risk of bladder cancer.
Cancer research - 1 Apr 2013
Garcia-Closas Montserrat, Rothman Nathaniel, Figueroa Jonine D, Prokunina-Olsson Ludmila, Han Summer S, Baris Dalsu, Jacobs Eric J, Malats Nuria, De Vivo Immaculata, Albanes Demetrius, Purdue Mark P, Sharma Sapna, Fu Yi-Ping, Kogevinas Manolis, Wang Zhaoming, Tang Wei, Tardón Adonina, Serra Consol, Carrato Alfredo, García-Closas Reina, Lloreta Josep, Johnson Alison, Schwenn Molly, Karagas Margaret R, Schned Alan, Andriole Gerald, Grubb Robert, Black Amanda, Gapstur Susan M, Thun Michael, Diver William Ryan, Weinstein Stephanie J, Virtamo Jarmo, Hunter David J, Caporaso Neil, Landi Maria Teresa, Hutchinson Amy, Burdett Laurie, Jacobs Kevin B, Yeager Meredith, Fraumeni Joseph F, Chanock Stephen J, Silverman Debra T, Chatterjee Nilanjan
Abstract excerpt
Bladder cancer results from the combined effects of environmental and genetic factors, smoking being the strongest risk factor. Evaluating absolute risks resulting from the joint effects of smoking and genetic factors is critical to assess the public health relevance of genetic information. Analyses included up to 3,942 cases and 5,680 controls of European background in seven studies. We tested for multiplicative...
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