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Unidirectional and Bidirectional Causation between Smoking and Blood DNA Methylation: Evidence from Twin-based Mendelian Randomisation

2024-06-20

Abstract excerpt

Cigarette smoking is associated with numerous differentially-methylated genomic loci in multiple human tissues. These associations are often assumed to reflect the causal effects of smoking on DNA methylation (DNAm), which may underpin some of the adverse health sequelae of smoking. However, prior causal analyses with Mendelian Randomisation (MR) have found limited support for such effects. Here, we apply an integ...

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Literature Corpus work
dce4d598-c4ab-59a1-8b01-c17f9ed4557f
DOI
10.1101/2024.06.19.24309184
Open publication

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Unidirectional and Bidirectional Causation between Smoking and Blood DNA Methylation: Evidence from Twin-based Mendelian RandomisationDOI 10.1101/2024.06.19.24309184
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