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Article

Lineage-Independent Tumors in Bilateral Neuroblastoma.

The New England journal of medicine - 5 Nov 2020

Coorens Tim H H, Farndon Sarah J, Mitchell Thomas J, Jain Neha, Lee Sangjin, Hubank Michael, Sebire Neil, Anderson John, Behjati Sam

Abstract excerpt

Childhood tumors that occur synchronously in different anatomical sites usually represent metastatic disease. However, such tumors can be independent neoplasms. We investigated whether cases of bilateral neuroblastoma represented independent tumors in two children with pathogenic germline mutations by genotyping somatic mutations shared between tumors and blood. Our results suggested that in both children, the...

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Identifiers

PMID: 33211929
DOI: 10.1056/NEJMoa2000962
PMCID: PMC7611571

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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