Article
Neuroblastoma in monozygotic twins with distinct presentation pathology and outcome: is it familial or in utero metastasis.
Pediatric blood & cancer - 1 Jun 2014
Abu-Arja Rolla, Hashem Hasan, El-Sheikh Ayman, Abusin Ghada
Abstract excerpt
To date ten sets of monozygotic twins with neuroblastoma have been reported in the literature. Twin-to-twin in utero metastasis have been proposed as the mechanism of tumor development in the second twin; based on similar pathology, presence of metastatic disease, absence of a primary tumor, and/or later presentation in the second twin. Hereditary neuroblastoma has not been described in this context. We propose...
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