Bilateral Germ Cell Tumor of the Testis: Biological and Clinical Implications for a Stem Versus Genetic Origin of Cancers.

doi:10.3390/cells14090658

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Article

Bilateral Germ Cell Tumor of the Testis: Biological and Clinical Implications for a Stem Versus Genetic Origin of Cancers.

Cells - 30 Apr 2025

Jackson Jamaal C, Sanchez Darren, Joon Aron Y, Estecio Marcos R, Johns Andrew C, Shah Amishi Y, Campbell Matthew, Ward John F, Pisters Louis L, Guo Charles C, Zhang Miao, Zacharias Niki M, Tu Shi-Ming

Abstract excerpt

Germ cell tumors of the testis (GCTs) provide an ideal tumor model to investigate the cellular versus genetic origin of cancers. In this single institutional study, we evaluated 38 patients with bilateral GCT, including tumors that occurred simultaneously (synchronous) and those occurring at different times (metachronous). For nine of these patients, DNA was isolated from the right and left GCT to determine the...

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Topics

Humans
Male
Testicular Neoplasms
Neoplasms, Germ Cell and Embryonal
DNA Methylation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Adult

Exome Sequencing

Middle Aged

Mutation

Seminoma

Epigenesis, Genetic

Young Adult

Source

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Identifiers

PMID: 40358182
DOI: 10.3390/cells14090658
PMCID: PMC12071550

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