Article
Ectopic neuroblastoma in monozygotic twins with different ages of onset: possible twin-to-twin metastasis in utero with distinct genetic alterations after birth.
Journal of pediatric hematology/oncology - 1 Mar 2014
Taketani Takeshi, Takita Junko, Ueyama Junichi, Kanai Rie, Kumori Koji, Maruyama Riruke, Hayashi Kazuhiko, Ogawa Seishi, Fukuda Seiji, Yamaguchi Seiji
Abstract excerpt
We describe neuroblastoma (NB) in monozygotic twins whose ages at the onset of the disease had a 3-year interval. The primary tumor site of twin 1 was the adrenal gland, whereas that of twin 2 was the jejunum/mesentery. MYCN amplification, DNA index, ALK mutation, and copy number alterations of DNA were different between each primary tumor. NB in ectopic sites may have resulted from twin-to-twin metastasis...
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