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Article

High-throughput detection of clinically relevant mutations in archived tumor samples by multiplexed PCR and next-generation sequencing.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Apr 2014

Bourgon Richard, Lu Shan, Yan Yibing, Lackner Mark R, Wang Weiru, Weigman Victor, Wang David, Guan Yinghui, Ryner Lisa, Koeppen Hartmut, Patel Rajesh, Hampton Garret M, Amler Lukas C, Wang Yulei

Abstract excerpt

PURPOSE: Tailoring cancer treatment to tumor molecular characteristics promises to make personalized medicine a reality. However, reliable genetic profiling of archived clinical specimens has been hindered by limited sensitivity and high false-positive rates. Here, we describe a novel methodology...

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PMID: 24573554
DOI: 10.1158/1078-0432.CCR-13-3114

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24573554-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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