Article
FFPE breast tumour blocks provide reliable sources of both germline and malignant DNA for investigation of genetic determinants of individual tumour responses to treatment.
Breast cancer research and treatment - 1 Aug 2018
Wilkins Anna, Chauhan Ritika, Rust Alistair, Pearson Alex, Daley Frances, Manodoro Floriana, Fenwick Kerry, Bliss Judith, Yarnold John, Somaiah Navita
Abstract excerpt
BACKGROUND: Bio-banked formalin-fixed paraffin-embedded (FFPE) tissues provide an excellent opportunity for translational genomic research. Historically matched blood has not always been collected as a source of germline DNA. This project aimed to establish if normal FFPE breast tissue could be used as an alternative to blood. METHODS: Exome sequencing was carried out on matched tumour tissue, normal breast...
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