Article
Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals.
Journal of molecular biology - 17 Oct 2003
Huerta Araceli M, Collado-Vides Julio
Abstract excerpt
We present here a computational analysis showing that sigma70 house-keeping promoters are located within zones with high densities of promoter-like signals in Escherichia coli, and we introduce strategies that allow for the correct computer prediction of sigma70 promoters. Based on 599 experimentally verified promoters of E.coli K-12, we generated and evaluated more than 200 weight matrices optimizing different...
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