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Article

Rewiring the specificity of extracytoplasmic function sigma factors.

Proceedings of the National Academy of Sciences of the United States of America - 29 Dec 2020

Todor Horia, Osadnik Hendrik, Campbell Elizabeth A, Myers Kevin S, Li Hao, Donohue Timothy J, Gross Carol A

Abstract excerpt

Bacterial genomes are being sequenced at an exponentially increasing rate, but our inability to decipher their transcriptional wiring limits our ability to derive new biology from these sequences. De novo determination of regulatory interactions requires accurate prediction of regulators' DNA binding and precise determination of biologically significant binding sites. Here we address these challenges by solving...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Bacterial

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Share to Promoter Regions, Genetic

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Source

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Identifiers

PMID: 33318184
DOI: 10.1073/pnas.2020204117
PMCID: PMC7776599

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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