Article
Mutation bias within oncogene families is related to proliferation-specific codon usage.
Proceedings of the National Academy of Sciences of the United States of America - 1 Dec 2020
Benisty Hannah, Weber Marc, Hernandez-Alias Xavier, Schaefer Martin H, Serrano Luis
Abstract excerpt
It is well known that in cancer gene families some members are more frequently mutated in tumor samples than their family counterparts. A paradigmatic case of this phenomenon is KRAS from the RAS family. Different explanations have been proposed ranging from differential interaction with other proteins to preferential expression or localization. Interestingly, it has been described that despite the high amino...
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