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Article

NAD+ depletion radiosensitizes 2-DG-treated glioma cells by abolishing metabolic adaptation.

Free radical biology & medicine - 1 Jan 2021

Shi Xiaolin, Zhang Wei, Gu Cheng, Ren Huangge, Wang Chen, Yin Narui, Wang Zhongmin, Yu Jiahua, Liu Fenju, Zhang Haowen

Abstract excerpt

Two-deoxy-d-glucose (2-DG) mediated glucose restriction (GR) has been applied as a potential therapeutic strategy for tumor clinical treatments. However, increasing evidences have indicated that 2-DG alone is inefficient in killing tumor cells, and the effect of 2-DG on modifying tumor radio-responses also remains controversial. In this study, we found that 2-DG triggered metabolic adaption in U87 glioma cells by...

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PMID: 33197538
DOI: 10.1016/j.freeradbiomed.2020.11.007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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