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Article

Development of an immuno-wall device for the rapid and sensitive detection of EGFR mutations in tumor tissues resected from lung cancer patients.

PloS one - 1 Jan 2020

Yogo Naoyuki, Hase Tetsunari, Kasama Toshihiro, Nishiyama Keine, Ozawa Naoya, Hatta Takahiro, Shibata Hirofumi, Sato Mitsuo, Komeda Kazuki, Kawabe Nozomi, Matsuoka Kohei, Chen-Yoshikawa Toyofumi Fengshi, Kaji Noritada, Tokeshi Manabu, Baba Yoshinobu, Hasegawa Yoshinori

Abstract excerpt

Detecting molecular targets in specimens from patients with lung cancer is essential for targeted therapy. Recently, we developed a highly sensitive, rapid-detection device (an immuno-wall device) that utilizes photoreactive polyvinyl alcohol immobilized with antibodies against a target protein via a streptavidin-biotin interaction. To evaluate its performance, we assayed epidermal growth factor receptor (EGFR)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33196648
DOI: 10.1371/journal.pone.0241422
PMCID: PMC7668601

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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