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Article

Highly sensitive EGFR mutation detection by specific amplification of mutant alleles.

Experimental and molecular pathology - 1 Feb 2014

Leelatian Nalin, Boonchoo Pichpisith, Wijitburaphat Sitsom, Moolsuwan Kanya, Wongjaroen Pattara, Chinnasang Priyakorn, Anyamaneeratch Komsan, Ruangchira-Urai Ruchira, Poungvarin Naravat

Abstract excerpt

Mutations in the tyrosine kinase domain of the epidermal growth factor receptor (EGFR) gene predict benefit from tyrosine kinase inhibitors in patients suffering from non-small-cell lung cancer. In this study, we developed a fast, simple, cost-effective and highly sensitive assay for detection of five clinically important EGFR mutations in exon 19 (2235_2249del and 2236_2250del), exon 20 (C2369T) and exon 21...

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Source

Identifiers

PMID: 24370549
DOI: 10.1016/j.yexmp.2013.12.006

Genes

EGFR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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