Article

Detecting EGFR Gene Mutations on a Nanobioarray Chip

2025-12-18

Abstract excerpt

In this study, three point mutations of EGFR relevant to lung cancer therapy are detected. Mutated EGFR is the target of a therapy for non-small cell lung cancer (NSCLC) using tyrosine kinase inhibitors (TKIs) as treatment drugs. Background/Objectives: Point mutations in exon 21 (L858R and L861Q) of the EGFR gene are TKI-sensitive; however, mutations in exon 20 (T790M) are TKI-resistant. Therefore, a fast detectio...

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Literature Corpus work: b7abca07-73d8-5314-9e30-530973b5b0d6
DOI: 10.20944/preprints202512.1447.v1

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