Combining Host Genetics and Functional Analysis to Depict Inflammasome Contribution in Tuberculosis Susceptibility and Outcome in Endemic Areas.

doi:10.3389/fimmu.2020.550624

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Combining Host Genetics and Functional Analysis to Depict Inflammasome Contribution in Tuberculosis Susceptibility and Outcome in Endemic Areas.

Frontiers in immunology - 1 Jan 2020

Souza De Lima Dhêmerson, Bomfim Caio C B, Leal Vinícius N C, Reis Edione C, Soares Jaíne L S, Fernandes Fernanda P, Amaral Eduardo P, Loures Flavio V, Ogusku Mauricio M, Lima Maria R D'Imperio, Sadahiro Aya, Pontillo Alessandra

Abstract excerpt

The interplay between M. tuberculosis (Mtb) and humans is multifactorial. The susceptibility/resistance profile and the establishment of clinical tuberculosis (TB) still remains elusive. The gain-of-function variant rs10754558 in the NLRP3 gene (found in 30% of the world population) confers protection against the development of TB, indicating a prominent role played by NLRP3 inflammasome against Mtb. Through...

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Identifiers

PMID: 33193317
DOI: 10.3389/fimmu.2020.550624
PMCID: PMC7609898

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