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Article

Human gene variants linked to enhanced NLRP3 activity limit intramacrophage growth of Mycobacterium tuberculosis.

The Journal of infectious diseases - 1 Mar 2014

Eklund Daniel, Welin Amanda, Andersson Henrik, Verma Deepti, Söderkvist Peter, Stendahl Olle, Särndahl Eva, Lerm Maria

Abstract excerpt

Activation of the NLRP3 inflammasome and subsequent generation of interleukin 1β is initiated in macrophages upon recognition of several stimuli. In the present work, we show that gain-of-function gene variants of inflammasome components known to predispose individuals to inflammatory disorders h...

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Source

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Identifiers

PMID: 24158955
DOI: 10.1093/infdis/jit572
PMCID: PMC3923544

Genes

NLRP3
CARD8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24158955-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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