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Article

Trace amine associated receptor 1: predicted effects of single nucleotide variants on structure-function in geographically diverse populations.

Human genomics - 11 Jun 2024

Shajan Britto, Marri Shashikanth, Bastiampillai Tarun, Gregory Karen J, Hellyer Shane D, Nair Pramod C

Abstract excerpt

Trace Amine Associated Receptor 1 (TAAR1) is a novel pharmaceutical target under investigation for the treatment of several neuropsychiatric conditions. TAAR1 single nucleotide variants (SNV) have been found in patients with schizophrenia and metabolic disorders. However, the frequency of variants in geographically diverse populations and the functional effects of such variants are unknown. In this study, we...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38863077
DOI: 10.1186/s40246-024-00620-w
PMCID: PMC11165750

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