A functional polymorphism in the ATP-Binding Cassette B1 transporter predicts pharmacologic response to combination of nortriptyline and morphine in neuropathic pain patients.

doi:10.1097/j.pain.0000000000001750

Article

A functional polymorphism in the ATP-Binding Cassette B1 transporter predicts pharmacologic response to combination of nortriptyline and morphine in neuropathic pain patients.

Pain - 1 Mar 2020

Benavides Rodrigo, Vsevolozhskaya Olga, Cattaneo Stefano, Zaykin Dmitri, Brenton Ashley, Parisien Marc, Verma Vivek, Khoury Samar, Gilron Ian, Diatchenko Luda

Abstract excerpt

Many genetic markers have been associated with variations in treatment response to analgesics, but none have been assessed in the context of combination therapies. In this study, the treatment effects of nortriptyline and morphine were tested for an association with genetic markers relevant to pain pathways. Treatment effects were determined for single and combination therapies. A total of 24 functional single...

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A functional polymorphism in the ATP-Binding Cassette B1 transporter predicts pharmacologic response to combination of nortriptyline and morphine in neuropathic pain patients.

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