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Article

Ring finger protein 43 expression is associated with genetic alteration status and poor prognosis among patients with intrahepatic cholangiocarcinoma.

Human pathology - 1 Jun 2016

Talabnin Chutima, Janthavon Patcharee, Thongsom Sunisa, Suginta Wipa, Talabnin Krajang, Wongkham Sopit

Abstract excerpt

Ring finger E3 ligases have roles in processes central to maintenance of genomic integrity and cellular homeostasis. Many ring finger E3 ligases are implicated in malignancy. Ring finger protein 43 (RNF43) is a ring finger E3 ligase that negatively regulates the Wnt/β-catenin signaling pathway. RNF43 is frequently mutated in several types of malignancy, including intrahepatic cholangiocarcinoma (ICC). The...

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Source

Identifiers

PMID: 26980022
DOI: 10.1016/j.humpath.2015.12.027

Genes

RNF43

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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