The E3 ligase RNF43 inhibits Wnt signaling downstream of mutated β-catenin by sequestering TCF4 to the nuclear membrane.

doi:10.1126/scisignal.aac6757

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Article

The E3 ligase RNF43 inhibits Wnt signaling downstream of mutated β-catenin by sequestering TCF4 to the nuclear membrane.

Science signaling - 8 Sept 2015

Loregger Anke, Grandl Martina, Mejías-Luque Raquel, Allgäuer Michael, Degenhart Kathrin, Haselmann Verena, Oikonomou Christina, Hatzis Pantelis, Janssen Klaus-Peter, Nitsche Ulrich, Gradl Dietmar, van den Broek Olaf, Destree Olivier, Ulm Kurt, Neumaier Michael, Kalali Behnam, Jung Andreas, Varela Ignacio, Schmid Roland M, Rad Roland, Busch Dirk H, Gerhard Markus

Abstract excerpt

Given its fundamental role in development and cancer, the Wnt-β-catenin signaling pathway is tightly controlled at multiple levels. RING finger protein 43 (RNF43) is an E3 ubiquitin ligase originally found in stem cells and proposed to inhibit Wnt signaling by interacting with the Wnt receptors of the Frizzled family. We detected endogenous RNF43 in the nucleus of human intestinal crypt and colon cancer cells. We...

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Identifiers

PMID: 26350900
DOI: 10.1126/scisignal.aac6757

Genes

RNF43
TCF4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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