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Article

Frequency and methylation status of selected retrotransposition competent L1 loci in amyotrophic lateral sclerosis.

Molecular brain - 13 Nov 2020

Savage Abigail L, Lopez Ana Illera, Iacoangeli Alfredo, Bubb Vivien J, Smith Bradley, Troakes Claire, Alahmady Nada, Koks Sulev, Schumann Gerald G, Al-Chalabi Ammar, Quinn John P

Abstract excerpt

Long interspersed element-1 (LINE-1/L1) is the only autonomous transposable element in the human genome that currently mobilises in both germline and somatic tissues. Recent studies have identified correlations between altered retrotransposon expression and the fatal neurodegenerative disease amyotrophic lateral sclerosis (ALS) in a subset of patients. The risk of an individual developing ALS is dependent on an...

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Identifiers

PMID: 33187550
DOI: 10.1186/s13041-020-00694-2
PMCID: PMC7666467

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