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Retrotransposition-competent L1s are increased in the genomes of individuals with amyotrophic lateral sclerosis

3 Jun 2025

Abstract excerpt

An individual's genetics contributes to their risk of developing amyotrophic lateral sclerosis (ALS); however, there is still a large proportion of the heritability of ALS to be understood. Part of this missing heritability may lie in complex variants, such as the long interspersed element 1 (L1) retrotransposon, which have yet to be evaluated. The majority of L1 insertions in the human genome are no longer able...

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PMID: 40529392
DOI: 10.3389/ebm.2025.10575

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