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Exploring epigenetic drift and rare epivariations in amyotrophic lateral sclerosis by epigenome-wide association study

27 Nov 2023

Abstract excerpt

During the last decades, our knowledge about the genetic architecture of sporadic amyotrophic lateral sclerosis (sALS) has significantly increased. However, besides the recognized genetic risk factors, also the environment is supposed to have a role in disease pathogenesis. Epigenetic modifications reflect the results of the interaction between environmental factors and genes and may play a role in the...

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PMID: 38090719
DOI: 10.3389/fnagi.2023.1272135

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