Article
The implications of DNA methylation for amyotrophic lateral sclerosis.
Anais da Academia Brasileira de Ciencias - 1 Jan 2023
Reis Adriana Helena DE Oliveira, Figalo Luna B, Orsini Marco, Lemos Bernardo
Abstract excerpt
Amyotrophic lateral sclerosis (ALS) is a complex and serious neurodegenerative disorder that develops in consequence of the progressive loss of the upper and lower motor neurons. Cases of ALS are classified as sporadic (sALS), or familial (fALS). Over 90% of cases are sALS, while roughly 10% are related to inherited genetic mutations (fALS). Approximately 70% of the genetic mutations that contribute to fALS have...
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