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Article

Characterization of Affitin proteolytic digestion in biorelevant media and improvement of their stabilities via protein engineering.

Scientific reports - 12 Nov 2020

Loussouarn Aurélie, Béhar Ghislaine, Pecorari Frédéric, Croyal Mikael, Renodon-Cornière Axelle

Abstract excerpt

Affitins are a novel class of small 7 kDa artificial proteins which can be used as antibody substitutes in therapeutic, diagnostic and biotechnological applications. One challenge for this type of protein agent is their behaviour in the context of oral administration. The digestive system is central, and biorelevant media have fast emerged as relevant and reliable tools for evaluating the bioavailability of...

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Share to Biological Availability
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 33184451
DOI: 10.1038/s41598-020-76855-z
PMCID: PMC7661517

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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