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Structure-Based Prediction of Asparagine and Aspartate Degradation Sites in Antibody Variable Regions

24 Jun 2014

Abstract excerpt

Monoclonal antibodies (mAbs) and proteins containing antibody domains are the most prevalent class of biotherapeutics in diverse indication areas. Today, established techniques such as immunization or phage display allow for an efficient generation of new mAbs. Besides functional properties, the stability of future therapeutic mAbs is a key selection criterion which is essential for the development of a drug...

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Share to Monoclonal and Polyclonal Antibodies Research
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PMID: 24959685
DOI: 10.1371/journal.pone.0100736

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