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Article

Dysregulated signalling pathways in innate immune cells with cystic fibrosis mutations.

Cellular and molecular life sciences : CMLS - 1 Nov 2020

Lara-Reyna Samuel, Holbrook Jonathan, Jarosz-Griffiths Heledd H, Peckham Daniel, McDermott Michael F

Abstract excerpt

Cystic fibrosis (CF) is one of the most common life-limiting recessive genetic disorders in Caucasians, caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR). CF is a multi-organ disease that involves the lungs, pancreas, sweat glands, digestive and reproductive systems and several other tissues. This debilitating condition is associated with recurrent lower respiratory tract...

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Source

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Identifiers

PMID: 32367193
DOI: 10.1007/s00018-020-03540-9
PMCID: PMC7599191

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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