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Article

An autonomous, but INSIG-modulated, role for the sterol sensing domain in mallostery-regulated ERAD of yeast HMG-CoA reductase.

The Journal of biological chemistry - 1 Jan 2000

Wangeline Margaret A, Hampton Randolph Y

Abstract excerpt

HMG-CoA reductase (HMGR) undergoes feedback-regulated degradation as part of sterol pathway control. Degradation of the yeast HMGR isozyme Hmg2 is controlled by the sterol pathway intermediate GGPP, which causes misfolding of Hmg2, leading to degradation by the HRD pathway; we call this process mallostery. We evaluated the role of the Hmg2 sterol sensing domain (SSD) in mallostery, as well as the involvement of...

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Identifiers

PMID: 33184059
DOI: 10.1074/jbc.RA120.015910
PMCID: PMC7948459

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Source receipt: pubmed, retrieved 7 Sept 2026.

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