Article
The prenyltransferase UBIAD1 is the target of geranylgeraniol in degradation of HMG CoA reductase.
eLife - 5 Mar 2015
Schumacher Marc M, Elsabrouty Rania, Seemann Joachim, Jo Youngah, DeBose-Boyd Russell A
Abstract excerpt
Schnyder corneal dystrophy (SCD) is an autosomal dominant disorder in humans characterized by abnormal accumulation of cholesterol in the cornea. SCD-associated mutations have been identified in the gene encoding UBIAD1, a prenyltransferase that synthesizes vitamin K2. Here, we show that sterols stimulate binding of UBIAD1 to the cholesterol biosynthetic enzyme HMG CoA reductase, which is subject to...
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