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Article

SCELLECTOR: ranking amplification bias in single cells using shallow sequencing.

BMC bioinformatics - 12 Nov 2020

Sarangi Vivekananda, Jourdon Alexandre, Bae Taejeong, Panda Arijit, Vaccarino Flora, Abyzov Alexej

Abstract excerpt

BACKGROUND: The study of mosaic mutation is important since it has been linked to cancer and various disorders. Single cell sequencing has become a powerful tool to study the genome of individual cells for the detection of mosaic mutations. The amount of DNA in a single cell needs to be amplified before sequencing and multiple displacement amplification (MDA) is widely used owing to its low error rate and long...

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Identifiers

PMID: 33183232
DOI: 10.1186/s12859-020-03858-y
PMCID: PMC7663899

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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