Article
Accurate single-cell genotyping utilizing information from the local genome territory.
Nucleic acids research - 4 Jun 2021
Tu Kailing, Lu Keying, Zhang Qilin, Huang Wei, Xie Dan
Abstract excerpt
Single-nucleotide variant (SNV) detection in the genome of single cells is affected by DNA amplification artefacts, including imbalanced alleles and early PCR errors. Existing single-cell genotyper accuracy often depends on the quality and coordination of both the target single-cell and external data, such as heterozygous profiles determined by bulk data. In most single-cell studies, information from different...
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