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Article

Haplotype phasing in single-cell DNA-sequencing data.

Bioinformatics (Oxford, England) - 1 Jul 2018

Satas Gryte, Raphael Benjamin J

Abstract excerpt

Motivation: Current technologies for single-cell DNA sequencing require whole-genome amplification (WGA), as a single cell contains too little DNA for direct sequencing. Unfortunately, WGA introduces biases in the resulting sequencing data, including non-uniformity in genome coverage and high rates of allele dropout. These biases complicate many downstream analyses, including the detection of genomic variants....

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Identifiers

PMID: 29950014
DOI: 10.1093/bioinformatics/bty286
PMCID: PMC6022575

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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