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Article

Distinct Roles of IL-1β and IL-18 in NLRC4-Induced Autoinflammation.

Frontiers in immunology - 1 Jan 2020

Sasaki Yuki, Otsuka Kunihiro, Arimochi Hideki, Tsukumo Shin-Ichi, Yasutomo Koji

Abstract excerpt

The NLRC4 inflammasome assembles in response to detection of bacterial invasion, and NLRC4 activation leads to the production of IL-1β and IL-18 together with pyroptosis-mediated cell death. Missense activating mutations in NLRC4 cause autoinflammatory disorders whose symptoms are distinctly dependent on the site of mutation and other aspects of the genetic background. To determine the involvement of IL-1β and...

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Identifiers

PMID: 33178225
DOI: 10.3389/fimmu.2020.591713
PMCID: PMC7592392

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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