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Article

Negative regulation of the NLRP3 inflammasome by A20 protects against arthritis.

Nature - 7 Aug 2014

Vande Walle Lieselotte, Van Opdenbosch Nina, Jacques Peggy, Fossoul Amelie, Verheugen Eveline, Vogel Peter, Beyaert Rudi, Elewaut Dirk, Kanneganti Thirumala-Devi, van Loo Geert, Lamkanfi Mohamed

Abstract excerpt

Rheumatoid arthritis is a chronic autoinflammatory disease that affects 1-2% of the world's population and is characterized by widespread joint inflammation. Interleukin-1 is an important mediator of cartilage destruction in rheumatic diseases, but our understanding of the upstream mechanisms leading to production of interleukin-1β in rheumatoid arthritis is limited by the absence of suitable mouse models of the...

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Share to Apoptosis Regulatory Proteins
Share to Caspase 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cysteine Endopeptidases

Share to Inflammasomes

Share to Interleukin-1

Share to NLR Family, Pyrin Domain-Containing 3 Protein

Share to Receptors, Interleukin-1

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Source

Open in PubMed Open full text

Identifiers

PMID: 25043000
DOI: 10.1038/nature13322
PMCID: PMC4126806

Genes

AIM2
NLRP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Negative regulation of NLRP3 inflammasome signalingSemantic proximity Read ↗

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