Article
An NLRP3 Mutation Causes Arthropathy and Osteoporosis in Humanized Mice.
Cell reports - 13 Dec 2016
Snouwaert John N, Nguyen MyTrang, Repenning Peter W, Dye Rebecca, Livingston Eric W, Kovarova Martina, Moy Sheryl S, Brigman Brian E, Bateman Ted A, Ting Jenny P-Y, Koller Beverly H
Abstract excerpt
The NLRP3 inflammasome plays a critical role in host defense by facilitating caspase I activation and maturation of IL-1β and IL-18, whereas dysregulation of inflammasome activity results in autoinflammatory disease. Factors regulating human NLRP3 activity that contribute to the phenotypic heterogeneity of NLRP3-related diseases have largely been inferred from the study of Nlrp3 mutant mice. By generating a mouse...
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